Hypothesis Refinement

The systems biology analysis approach is driven by the hypothesis of the experiment, i.e., the research scientists experimental hypotheses which are to be confirmed experimentally. The design of experiments needs to define the approach to be followed in the experiment, but also must be defined in consideration of the bioinformatics. Seralogix staff should be included early in the design of experiments so that the data collected can be factored into defining the computational objectives.

Specific support activities for clients include development and review of design of experiments and statistical consultation. This support includs power calculations and guidance on sampling times and replicates for any given type of biological study such as gene knockouts or other multi-conditional perturbation studies.

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Systems Biology Refinement Cycle